Files @ da628cac41fc
Branch filter:

Location: EI/VirtualLeaf/src/cellbase.h

Michael Guravage
Use the wallnumber (wn) to discern which cell a wallitem belongs to.

--
user: Michael Guravage <michael.guravage@cwi.nl>
branch 'default'
changed src/ChangeLog
changed src/transporterdialog.cpp
changed src/wallitem.cpp
  1
  2
  3
  4
  5
  6
  7
  8
  9
 10
 11
 12
 13
 14
 15
 16
 17
 18
 19
 20
 21
 22
 23
 24
 25
 26
 27
 28
 29
 30
 31
 32
 33
 34
 35
 36
 37
 38
 39
 40
 41
 42
 43
 44
 45
 46
 47
 48
 49
 50
 51
 52
 53
 54
 55
 56
 57
 58
 59
 60
 61
 62
 63
 64
 65
 66
 67
 68
 69
 70
 71
 72
 73
 74
 75
 76
 77
 78
 79
 80
 81
 82
 83
 84
 85
 86
 87
 88
 89
 90
 91
 92
 93
 94
 95
 96
 97
 98
 99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
/*
 *
 *  $Id$
 *
 *  This file is part of the Virtual Leaf.
 *
 *  VirtualLeaf is free software: you can redistribute it and/or modify
 *  it under the terms of the GNU General Public License as published by
 *  the Free Software Foundation, either version 3 of the License, or
 *  (at your option) any later version.
 *
 *  VirtualLeaf is distributed in the hope that it will be useful,
 *  but WITHOUT ANY WARRANTY; without even the implied warranty of
 *  MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
 *  GNU General Public License for more details.
 *
 *  You should have received a copy of the GNU General Public License
 *  along with the Virtual Leaf.  If not, see <http://www.gnu.org/licenses/>.
 *
 *  Copyright 2010 Roeland Merks.
 *
 */

// CellBase derives from Vector, where Vector is simply used as a Vertex

#ifndef _CELLBASE_H_
#define _CELLBASE_H_

#include <list>
#include <vector>
#include <iostream>
#include <QString>
#include <QDebug>

#include "vector.h"
#include "parameter.h"
#include "wall.h"
#include "warning.h"
#include "assert.h"

extern Parameter par;
using namespace std;

class Mesh;
class Node;
class CellBase;
class NodeSet;

struct ParentInfo {

  Vector polarization;
  double PINmembrane;
  double PINendosome;
};

// We need a little trick here, to make sure the plugin and the main application will see the same static datamembers
// otherwise each have their own instantation.
// My solution is as follows. I collect all original statics in a class. The main application instantiates it and
// has a static pointer to it. After loading the plugin I set a static pointer to the same class 
class CellsStaticDatamembers {

 public:
  CellsStaticDatamembers(void) {
    ncells = 0;
    nchem = 0;
    base_area = 0.;
  }
  ~CellsStaticDatamembers() {
#ifdef QDEBUG
    qDebug() << "Oops! Desctructor of CellsStaticDatamembers called" << endl;
#endif
  }
  int ncells;
  int nchem;
  double base_area;
};

class CellBase :  public QObject, public Vector 
{

  Q_OBJECT

  friend class Mesh;
  friend class CellInfo;
  friend class Node;
  friend class WallBase;
  friend class SimPluginInterface;

 public:
  CellBase(QObject *parent=0);
  CellBase(double x,double y,double z=0); // constructor

  virtual ~CellBase() {
    delete[] chem;
    delete[] new_chem;
    if (division_axis) delete division_axis;
    //cerr << "CellBase " << index << " is dying. " << endl;
  }

  CellBase(const CellBase &src); // copy constructor
  virtual bool BoundaryPolP(void) const { return false; } 


  CellBase operator=(const CellBase &src); // assignment operator
  CellBase operator=(const Vector &src);

  void SetChemical(int chem, double conc);
  inline void SetNewChem(int chem, double conc)
  { 
    new_chem[chem] = conc;
  }

  void SetSource(int chem, double conc)
  {
    source=true;
    source_chem = chem;
    source_conc = conc;
  }

  // set chem 1 to conc in all membranes of this cell
  void SetTransporters(int chem, double conc);
  void UnfixNodes(void);
  void FixNodes(void);
  void UnsetSource(void) {
    source = false;
  }

  inline bool Source(void) { return source; }
  enum boundary_type {None, Noflux, SourceSink, SAM};
  static const char * boundary_type_names[4];

  inline const char *BoundaryStr(void) { return boundary_type_names[boundary]; }

  ostream &print(ostream &os) const;

  inline double Chemical(int c) const { // returns the value of chemical c
#ifdef _undefined_
    qDebug() << endl << "Entering cellbase::chemical(" << c << "), and nchem is: " << NChem() << "." << endl;
#endif

    int nchem = NChem();

#ifdef _undefined_
    if ((c<0) || (c>=nchem))
      MyWarning::warning("CellBase::Chemical says: index c is: %d, but nchem is: %d. Merely return zero", c, nchem);
#endif

    return ((c<0) || (c>=nchem)) ? 0 : chem[c];
  }


  //void print_nblist(void) const;

  boundary_type SetBoundary(boundary_type bound)
  {
    if (bound!=None) {
    }
    return boundary=bound;
  }

  boundary_type ResetBoundary(void) { return boundary=None; }

  boundary_type Boundary(void) const { return boundary; }

  static int &NChem(void) { return static_data_members->nchem; }

  double CalcArea(void) const;

  double RecalcArea(void) { return area = CalcArea(); }

  Vector Centroid(void) const;

  void SetIntegrals(void) const;

  double Length(Vector *long_axis = 0, double *width = 0) const;
  double CalcLength(Vector *long_axis = 0, double *width = 0) const;

  double ExactCircumference(void) const;
  inline int Index(void) const { return index; }


  void SetTargetArea(double tar_ar) { target_area=tar_ar; }

  inline void SetTargetLength(double tar_l) { target_length=tar_l; }

  inline void SetLambdaLength(double lambda_length) { lambda_celllength = lambda_length; }

  inline double TargetArea(void) { return target_area; }

  inline void SetStiffness(double stiff) { stiffness = stiff; }

  inline double Stiffness(void) { return stiffness; }

  inline double EnlargeTargetArea(double da) { return target_area+=da; }

  inline double Area(void) const { return area; }

  inline void Divide(void) { flag_for_divide = true; }

  inline void DivideOverAxis(const Vector &v)
  {
    division_axis = new Vector(v);
    flag_for_divide = true;
  }

  inline double WallCircumference(void) const {
    double sum=0.;
    for (list<Wall *>::const_iterator w=walls.begin();
	 w!=walls.end();
	 w++) {
      sum +=  (*w)->Length();
    }

    return sum;
  }

  QList<WallBase *> getWalls(void) {
    QList<WallBase *> wall_list;
    for (list<Wall *>::iterator i=walls.begin();
	 i!=walls.end();
	 i++) {
      wall_list << *i;
    }
    return wall_list;
  }

  void Dump(ostream &os) const;

  QString printednodelist(void);

  inline bool DeadP(void) { return dead; }
  inline void MarkDead(void) { dead  = true; }

  static double &BaseArea(void)
  { 
    return static_data_members->base_area;
  }

  void CheckForDivision(void);

  // write flux from neighboring cells into "flux"
  void Flux(double *flux, double *D); 
  inline bool FixedP(void) { return fixed; }
  inline bool Fix(void) {  FixNodes(); return (fixed=true); }
  inline bool Unfix(void) { UnfixNodes(); return (fixed=false);}
  inline void setCellVec(Vector cv) { cellvec = cv; }

  bool AtBoundaryP(void) const;

  static inline int &NCells(void)
  {
    return static_data_members->ncells;
  }

  inline void Mark(void)
  {
    marked=true;
  }

  inline void Unmark(void)
  {
    marked=false;
  }

  inline bool Marked(void) const {
    return marked;
  }

  //! Returns the sum of chemical "chem" of this CellBase's neighbors
  double SumChemicalsOfNeighbors(int chem)
  {
    double sum=0.;
    for (list<Wall *>::const_iterator w=walls.begin();
	 w!=walls.end();
	 w++) {
      sum +=  (*w)->Length() * ( (*w)->c1!=this ? (*w)->c1->Chemical(chem) : (*w)->c2->Chemical(chem) );
    }
    return sum;
  }

  //! Generalization of the previous member function
  template<class P, class Op> P ReduceNeighbors(Op f) {
    P sum=0;
    for (list<Wall *>::const_iterator w=walls.begin();
	 w!=walls.end();
	 w++) {
      sum += (*w)->c1 != this ? f( *((*w)->c1) ) : f ( *((*w)->c2) ); 
    }
    return sum;
  }

  //! The same, but now for the walls
  template<class P, class Op> P ReduceWalls(Op f, P sum) {
    for (list<Wall *>::const_iterator w=walls.begin();
	 w!=walls.end();
	 w++) {
      sum += f( **w ); 
    }
    return sum;
  }

  //! The same, but now for the walls AND neighbors
  template<class P, class Op> P ReduceCellAndWalls(Op f)
  {
    P sum = 0;
    for (list<Wall *>::const_iterator w=walls.begin();
	 w!=walls.end();
	 w++) {
      sum += ((*w)->c1 == this) ? 
	f( ((*w)->c1), ((*w)->c2), *w ) :  
	f( ((*w)->c2), ((*w)->c1), *w );
    }
    return sum;
  }


  //! Sum transporters at this CellBase's side of the walls
  double SumTransporters(int ch)
  {
    double sum=0.;
    for (list<Wall *>::const_iterator w=walls.begin();
	 w!=walls.end();
	 w++) {
      sum += (*w)->getTransporter(this, ch);

    }
    return sum;
  }

  inline int NumberOfDivisions(void) { return div_counter; }

  //! Sum transporters at this CellBase's side of the walls
  double SumLengthTransporters(int ch)
  {
    double sum=0.;
    for (list<Wall *>::const_iterator w=walls.begin();
	 w!=walls.end();
	 w++) {
      sum += (*w)->getTransporter(this, ch) * (*w)->Length();

    }
    return sum;
  }



  double SumLengthTransportersChemical(int trch, int ch)
  {
    double sum=0.;
    for (list<Wall *>::const_iterator w=walls.begin();
	 w!=walls.end();
	 w++) {
      sum += (*w)->getTransporter(this, trch) * ( (*w)->c1!=this ? (*w)->c1->Chemical(ch) : (*w)->c2->Chemical(ch) );

    }
    return sum;
  }
  inline int CellType(void) const { return cell_type; } 
  inline void SetCellType(int ct) { cell_type = ct; }


  static void SetNChem(int new_nchem)
  {
    if (NCells()) {
      MyWarning::error("CellBase::SetNChem says: not permitted, call SetNChem after deleting all cells.");
    } else {
      NChem() = new_nchem;
    }
  }

  inline double TargetLength() const { return target_length; } 

  static inline CellsStaticDatamembers *GetStaticDataMemberPointer(void) { return static_data_members; }

 protected:
  // (define a list of Node* iterators)
  typedef list < list<Node *>::iterator > ItList;

  int index;

  inline void SetChemToNewchem(void)
  {
    for (int c=0;c<CellBase::NChem();c++) {
      chem[c]=new_chem[c];
    }
  }
  inline void SetNewChemToChem(void)
  {
    for (int c=0;c<CellBase::NChem();c++) {
      new_chem[c]=chem[c];
    }
  }
  inline double NewChem(int c) const { return new_chem[c]; }

 protected:
  list<Node *> nodes;
  void ConstructNeighborList(void);
  long wall_list_index (Wall *elem) const;

  // DATA MEMBERS

  // list of nodes, in clockwise order

  // a (non-ordered) list of neighboring cells (actually I think the
  // introduction of ConstructWalls() has made these
  // lists ordered (clockwise), but I am not yet 100% sure...).
  list<CellBase *> neighbors;

  list<Wall *> walls;

  double *chem;
  double *new_chem;

  boundary_type boundary;
  mutable double area;
  double target_area;
  double target_length;
  double lambda_celllength;

  double stiffness; // stiffness like in Hogeweg (2000)

  bool fixed;
  bool pin_fixed;
  bool at_boundary; 
  bool dead; 
  bool flag_for_divide;

  Vector *division_axis;
  int cell_type;

  // for length constraint
  mutable double intgrl_xx, intgrl_xy, intgrl_yy, intgrl_x, intgrl_y;

  bool source;
  Vector cellvec;

  // STATIC DATAMEMBERS MOVED TO CLASS
  static CellsStaticDatamembers *static_data_members;
  double source_conc;
  int source_chem;

  // PRIVATE MEMBER FUNCTIONS
  inline static void ClearNCells(void)
  {
    NCells()=0;
  }

  bool marked;
  int div_counter;
};

ostream &operator<<(ostream &os, const CellBase &v);

inline Vector PINdir(CellBase *here, CellBase *nb, Wall *w)
{
  return w->getTransporter( here, 1)  *  w->getInfluxVector(here);
}

#endif

/* finis*/